• In addition we aimed to

  2023-12-22

  

  In addition, we aimed to examine the possible role of adiponectin in modulating changes in IR. It was observed that there was a simultaneous decline in expression of IR and AdipoR1 proteins in the ovary of PCOS-mice as compared to the control ovary. Further, a strong correlation was found between ch

• Small RhoGTPases are single domain nucleotide dependent bina

  2023-12-22

  

  Small RhoGTPases are single-domain nucleotide-dependent binary switches that act as highly-tuned regulators in signal transduction [1]. The cycling between active GTP-bound and inactive GDP-bound forms allows RhoGTPases to bind to or to dissociate from downstream effectors, respectively [2]. Guanine

• T7 High Yield Fluorescein RNA receptor NSAIDs induce gastroi

  2023-12-22

  

  NSAIDs induce gastrointestinal toxicity and evoke T7 High Yield Fluorescein RNA receptor by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001

• GSK 4112 The introduction of a pyrazole moiety

  2023-12-22

  

  The introduction of a pyrazole moiety into any position of the sterane core by cross-coupling reactions [13] or by Knorr construction from a CCC bis-electrophilic sterane precursor and an N,N binucleophile building block [17], [19] may serve as an example. Very few reports are to be found, however,

• br The human CYP A gene is located on chromosome

  2023-12-22

  

  The human CYP17A1 gene is located on chromosome 10q24.3 (1) and spans 6.6 kb, which contain eight exons (2) and 1.6 kb of coding region. From this gene, the same 2.1-kb mRNA species is transcribed in both the adrenals and gonads (3), which yields a 57-kDa microsomal cytochrome P450c17 enzyme (CYP1

• In conclusion AXL overexpression preexisted in a subgroup

  2023-12-22

  

  In conclusion, AXL overexpression preexisted in a subgroup of treatment-naive lung adenocarcinoma specimens harboring an activating EGFR mutation or in those with wild-type EGFR. Anti-AXL therapeutics delivered up front in combination with the EGFR inhibitor might overcome intrinsic or acquired resi

• br Autophagy and cell death pathways in

  2023-12-22

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Cy3 carboxylic acid (non-sulfonated) injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with

• br Autophagy inducers Macroautophagy is often seen as a cell

  2023-12-22

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of TH287 and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivity of cance

• The reproducibility of the IC measurements in

  2023-12-21

  

  The reproducibility of the IC50 measurements in the Pf-dhfr yeast was far better than comparable measurements in P. falciparum in vitro [1]. This is probably due to the extremely low level of folate and para-aminobenzoic Cerulenin in the yeast growth medium. This is in contrast to culture of P. fal

• Sorafenib was the first small RTK inhibitor drug

  2023-12-21

  

  Sorafenib was the first small RTK inhibitor drug to be developed and was initially approved against renal cell carcinoma, then against hepatocellular carcinoma (HCC) and more recently for differentiated thyroid treatment [111]. Sunitinib soon followed, being approved for gastrointestinal stromal tum

• Although mature fibrils formed from A aggregates

  2023-12-21

  

  Although mature fibrils formed from Aβ orexin antagonist have long been thought to be the main neurodegenerative agents in AD, recent evidence suggests that soluble multimers of these pathogenic proteins, referred to here as “oligomers,” may initiate the synaptic and neuronal dysfunction associated

• br Acknowledgments and Disclosures br Introduction Over

  2023-12-21

  

  Acknowledgments and Disclosures Introduction Over the last decade, the most visible strategy for the treatment of Alzheimer's disease (AD) has been amyloid β peptide (Aβ) immunotherapy (reviewed in [1]). Although the first efforts with Aβ immunotherapy failed to complete clinical trials [1],

• Brilliant Blue G br Results br Discussion Cardiac

  2023-12-21

  

  Results Discussion Cardiac dysfunction, common complication of severe sepsis, is one cause of death in intensive care units. Accumulated evidence revealed the regulatory effect of autophagy on sepsis-induced cardiac dysfunction [15], [22], although the mechanisms in young and aging are not elu

• Platelet derived growth factor PDGF and ciliary neurotrophic

  2023-12-21

  

  Platelet-derived growth factor (PDGF) and ciliary neurotrophic factor (CNTF) are expressed by glial SU 9516 receptor and are important to neuron survival and the maintenance of oligodendrocytes. These neurotrophic factors contribute to the remyelination process by increasing the proliferation of ol

• br ABCA and cancer drug response

  2023-12-21

  

  ABCA2 and cancer drug response Overall, the expression of ABC transporters has been linked with multidrug resistance phenotypes through the efflux of drugs via ATP-dependent transport. For example, 13 distinct transporters (ABCA2, ABCB1, ABCB4, ABCB11, ABCC1–6 ABCC10, ABCC11 and ABCG2) have been

13208 records 71/881 page Previous Next First page 上5页 7172737475 下5页 Last page