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In summary PPARG and FFAR are connected in several ways
2022-07-16
In summary, PPARG and FFAR1 are connected in several ways, and the presented interaction is mechanistically reasonable. Additional investigations are required to elucidate the exact details of the underlying physiology. However, our findings are of immanent importance for the treatment of type 2 dia
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br Promotion of GLS expression Glutamine metabolism is anoth
2022-07-16
Promotion of GLS2 expression Glutamine metabolism is another target for alteration in ferroptosis. Glutamine is required for the induction of ferroptosis during serum-induced injury after amino U-104 starvation [72]. The first step of glutamine catabolism is its conversion to glutamate, which is
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br Conclusions br Conflicts of
2022-07-15
Conclusions Conflicts of interest Funding The research work was partially supported by National Science Center (Contract Grant Number: UMO-2015/19/B/NZ1/00332). Introduction Frusectose-1, 6-bisphosphatase (FBPase) has long been recognized as a potential therapeutic target for the treatm
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The molecular target of N BPs is
2022-07-15
The molecular target of N-BPs is farnesyl diphosphate synthase (FPPS), a crucial enzyme at the branch point of cholesterol and isoprenoid synthesis in the mevalonate pathway [5]. Because they bind calcium ions, N-BPs accumulate quickly in the skeleton and are internalised by osteoclasts, leading to
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Histamine H and H receptor expression is altered
2022-07-15
Histamine H2 and H3 receptor expression is altered in the p2x of Hdc mice (Chepkova et al, 2012, Fitzsimons and et al, 2001). Because these mice lack HA, expression of HA receptors might be thought to be irrelevant. This is not the case in Hdc heterozygotes, however, or in patients with a heterozyg
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Of the many thousands of
2022-07-15
Of the many thousands of mutations analyzed in tracheal terminal cells, less than a handful affect tube morphology specifically in the transition zone (Baer et al., 2007, Beitel and Krasnow, 2000, Förster et al., 2010, Ghabrial et al., 2011, Myat et al., 2005, Ruiz et al., 2012, Samakovlis et al., 1
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Nevertheless the frequency of CTCs was
2022-07-15
Nevertheless, the frequency of CTCs was higher in patients with metastatic breast cancer, which is to be expected because cancer TWS119 from the original clone that caused the metastasis probably had features favoring their spread throughout the body. When we take HER2+ CTC counts ≥ 3 as a “strong”
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br Ethical approve and consent to participate br Consent
2022-07-15
Ethical approve and consent to participate Consent for publication Availability of supporting data Competing interests Funding This work was supported by a grant from Key Program of National Natural Science Foundation of China (No. 81330089) and the Shanghai Science and Technology Fun
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Matrine Metallothioneins MTs that are intracellular proteins
2022-07-15
Metallothioneins (MTs) that are intracellular proteins responsible for the maintenance of metal homeostasis are involved in arsenic toxicity (Kita et al., 2006). Four major MT isoforms have been reported so far, MT1, MT2A, MT3 and MT4. The synthesis of MT1 and MT2A isoforms in mammal cells can be in
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Following our initial observation of an unexpected increase
2022-07-15
Following our initial observation of an unexpected increase in the maximal rates of cGMP formation by NO-stimulated sGC in the presence of cytosolic PCA preparations [15], we attempted to purify, identify and characterize the responsible protein(s). The purification protocol described in the present
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br Positive regulation of gene
2022-07-15
Positive regulation of gene BCTC by Nrf2 Repression of Nrf2 by Keap1 Because many xenobiotic inducers of NQO1 and GST enzyme activities contain a thiol-reactive electrophilic moiety (i.e. are soft electrophiles), Paul Talalay and colleagues predicted in 1988 that they would be recognized with
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br Methods br Transfollicular penetration of herbs and their
2022-07-15
Methods Transfollicular penetration of herbs and their active constituents used for hair loss treatment The transfollicular administration of pharmacologically active molecules is recognised as a significant element for therapeutic interest, mainly with regard to delivery to specific sites of
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Famprofazone In addition researchers studying GPR agonists f
2022-07-15
In addition, researchers studying GPR119 agonists favor the developing of candidate drugs that are more potent than DPP-4 inhibitors given that the latter are moderate agents in the treatment of DM. Although it Famprofazone is unclear why Sanofi-Aventis chose to terminate collaboration with Metabol
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While NR upregulation in the spinal cord is
2022-07-15
While NR1 upregulation in the spinal cord is known to contribute to pathological pain [7], [22] and furthermore, NR1 expression in the spinal cord has been shown to be reduced by continuous administration of the GlyT1-inhibitor ALX5407 [23], little is known about possible expressional changes of NR1
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Neurotransmitter transporters are rapidly recycled from and
2022-07-15
Neurotransmitter transporters are rapidly recycled from and to the membrane. For instance, the GABA transporter GAT1 is recycled in a calcium and depolarization dependent manner. GAT1 located in the plasma membrane is internalized to a subpopulation of small vesicles different from the classical neu
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