• Curcumin is able to upregulate the protein level of NGF

  2023-03-20

  

  Curcumin is able to upregulate the protein level of NGF through cannabinoid receptor CB1, where the activation of Akt pathway probably plays an important part in the CB1-mediated signal transmission [9,10]. This finding suggested that the protection of curcumin in spinal motor neurons of SNI rats is

• In another study authors found

  2023-03-20

  

  In another study, authors found that ADORA1 were present on the intrinsically photosensitive retinal ganglion filgotinib (ipRGCs), and application of adenosine to rat retinas reduced light-evoked spiking of ipRGCs through suppression of a cAMP-mediated pathway (Sodhi and Hartwick, 2014). The ipRGCs

• br Results and discussion The morphology and structure of

  2023-03-20

  

  Results and discussion The morphology and structure of DPQ samples were observed using an SEM, as shown in Fig. 1. The length and thickness of the actin filaments were regulated with ABPs to mimic the various actins observed in cells. We prepared three types of F-actin with or without gelsolin t

• In summary this study reveals that the

  2023-03-20

  

  In summary, this study reveals that the stability of rapsyn is critically dependent on HSP90β, highlighting a novel function of HSP90β in NMJ formation and maintenance. It also identifies a mechanism in agrin signaling for AChR clustering, i.e., by upregulating the interaction between HSP90β and rap

• br Acknowledgments The authors would like

  2023-03-17

  

  Acknowledgments The authors would like to thank Ms. Ashley Davis for her administrative assistance in preparing this article and Mr. Dan Beck for his artistic contributions to Fig. 1. Introduction Acetylcholine is the most abundant neurotransmitter in the central nervous system (CNS) of insec

• br Autophagy inducers Macroautophagy is often seen as a cell

  2023-03-17

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of Motilin Receptor and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivi

• br Materials and methods br

  2023-03-17

  

  Materials and methods Results Discussion In the present study, we found that SSTR2, SSTR5, and DA2R proteins are expressed in ACTH-positive melanin inhibitor in healthy canine pituitary glands, with particularly high positive cell ratios in the intermediate lobes. Somatostatin has been rep

• Here the so called alkali assay is proposed as a

  2023-03-17

  

  Here the so-called alkali assay [18] is proposed as a method to be applied directly on the purified recombinant enzyme sharing the same structural and functional features of the wild-type enzyme [19], [20], [21] using its physiological substrate androstenedione. The assay that was already successful

• br AR expression in breast

  2023-03-17

  

  AR expression in breast tissue Although androgenic signalling is chiefly associated with the development and maintenance of primary and secondary male characteristics, especially during puberty when the testes are by far the major source of testosterone, the AR also plays important functions in f

• In summary our data have

  2023-03-17

  

  In summary, our data have shown that one mechanism by which glucose may mediate monocyte–endothelial cell interaction in the retinal endothelial cells is via the 12/15-LO pathway Furthermore, our current and previously published data [20,22] indicate a differential role of endothelial 12/15-LO versu

• br Endocytosis of AdipoR Surface receptor

  2023-03-17

  

  Endocytosis of AdipoR1 Surface receptor activity may be shut down by endocytic uptake and subsequent lysosomal degradation of the proteins [20]. Clathrin-dependent endocytosis (CDE) has been extensively studied and internalization from the plasma membrane is mediated through clathrin-coated pits

• The hypothalamic pituitary adrenal HPA axis is a neuroendocr

  2023-03-16

  

  The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine system that is central to regulating responses to stress (Palazidou, 2012). In older persons, a high dysfunction of the HPA axis is observed (Otte et al., 2005) which may be enhanced by stimulatory effects of genes involved in the axi

• br Acknowledgements br Introduction Resistant hypertension

  2023-03-16

  

  Acknowledgements Introduction Resistant hypertension (RH), is defined as blood pressure (BP) > 140/90 mm Hg despite three full doses antihypertensive drugs including a diuretic. Controlled hypertensive patients taking four (3S,5S)-Atorvastatin sodium salt or more of antihypertensives are also

• Because LTs are proved to mediate

  2023-03-16

  

  Because LTs are proved to mediate multiple biological and pathological responses in various disease states, the 5-LO biosynthetic pathway producing LTs from AA have been the target of drug discovery efforts for over two decades. As observed from literature, a pile of research efforts has been direct

• The Kelch like ECH associated protein Keap Nrf signaling pat

  2023-03-16

  

  The Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 signaling pathway functions as one of the key regulator of the cellular defense system against oxidative stress [26]. Nrf2 is a redox-sensitive transcription factor, that is sequestered in the cytoplam by binding to Keap1; however, under oxidative

13154 records 166/877 page Previous Next First page 上5页 166167168169170 下5页 Last page