chloride channels Furthermore collagen could be further util
Furthermore, collagen could be further utilized to surface modification of biologically inert materials, such as polymer materials and metal materials, which are always hydrophobic, lacking functional groups and poor cell adhesion. Therefore, various strategies have been tested to improve the properties of these materials including plasma deposition processes, surface immobilization of biopolymers (e.g. gelatin, chitosan, collagen), attachment of bioactive chloride channels (RGD peptide) and surface mineralization [49,50]. The group of Inês Sousa modified PCL scaffold with plasma treatment, then acrylic acid grafting and collagen immobilization to improve the hydrophily and cell adhesion of PCL . The bio-function dendrimer is shown in Fig. 7 .
Recent biomedical applications of collagen based materials
Conclusion and future prospects
Acknowledgements This work is supported by National Natural Science Foundation of China (21808133, 21804084), Scientific Research Foundation for Young Scholars (contract grant number 2017BT-32), Shaanxi University of Science & Technology, Shaanxi Province Key R&D Program (2018ZDXM-SF-091).