In contrast to adults PBL in children is

In purchase Z-VEID-FMK to adults, PBL in children is regarded as a clinical entity that is distinct from its adult counterpart. Like many other pediatric malignancies, PBL is considered a systemic disease in children. In small retrospective studies, PBL in children is characterized by rapid progression, a higher incidence of micrometastasis, and a propensity for spread to the central nervous system, yet children have a better prognosis [16]. In a multivariate analysis, adult patients who had local disease and who were younger had a significant survival advantage. Similarly, there was a significant association between young age and a histological classification of “NHL-Large B-cell diffuse”. A survival analysis of patients with localized disease revealed that radiation therapy was associated with improved survival, whereas surgery did not prove to be of survival benefit [16]. A current study [16] supports sub-classification of group of patient with PBL who have localized disease because there is a difference in their prognosis and outcome compared with patients who have other, more extensive disease.
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