• Romiplostim is an Fc fusion protein

  2019-04-23

  

  Romiplostim is an Fc-fusion protein that augments thrombopoiesis by binding to and activating the thrombopoietin receptor. It is approved for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglo

• br In the past decade Brazil has achieved considerable progr

  2019-04-23

  

  In the past decade, Brazil has achieved considerable progress in malaria control, with 140 000 cases reported in 2015, the lowest numbers since 1980. Part of this success has been attributed to the establishment of a large network of around 3000 diagnostic and treatment units for malaria. A remark

• Numbers studies also showed that the MSCs have

  2019-04-23

  

  Numbers studies also showed that the MSCs have the capacity to differentiate into multiple mesenchymal tissues both in vitro and in vivo, including osteoblast [25,34], condrocyte [35,36], adipocyte [37,38], tendon [39,40], skeletal muscle cells [39], cardiomyocyte [41,42] and hematopoietic supportin

• Pellicer alude a esta leyenda varias veces

  2019-04-22

  

  Pellicer alude Eosin Y esta leyenda varias veces en “Oda a Cuauhtémoc”, con imágenes que sugieren la batalla con un astro, la estrella de la aurora de Quetzalcóatl, que en el poema representa un destino fatal: “El arco negro se tendió ante la aurora / y en el último astro fue a clavarse la flecha” (

• Fashions are dangerous things But it

  2019-04-22

  

  Fashions are dangerous things. But it ginsenoside rh2 seems that global health is no ephemeral trend. Every year, the field grows stronger. The Consortium of Universities for Global Health (CUGH) is a young organisation—its 2014 conference is only its fifth annual meeting. But in this short time, C

• In conclusion we demonstrated that cells with the standard

  2019-04-22

  

  In conclusion, we demonstrated that membrane transport with the standard Ph had no detectable BCR–ABL1 KD mutations and that they were responsive to imatinib therapy, while cells with the variant translocation harbored two KD mutations, a previously described one and a never previously reported one

• br Discussion The natural history

  2019-04-22

  

  Discussion The natural history of PMF is characterized by the possibility of blastic transformation in approximately 20% of all the cases [9]. Several factors might predict leukemic transformation, including percentage of circulating blasts, low platelets count and the presence of an unfavorable

• In Taiwan the crude incidence rate of

  2019-04-22

  

  In Taiwan, the crude incidence rate of colorectal cancer among male and female populations increased from 49.98 to 69.90, and 39.48 to 51.36 per 100,000 people, respectively, during the DIG-11-dUTP between 2006 and 2011. The observed 2-year survival rates of colon cancer in 2004–2006, 2007–2009 and

• We herein report a patient

  2019-04-22

  

  We herein report a patient with dMMR and MSI-H metastatic gastric cancer who prostaglandin receptor responded favorably and durably to PD-1 blockade. This patient, along with the previous two demonstrated by Le et al, are up-to-date the only 3 MMR gastric cancer patients who responded well to PD-1

• br Case report His physical examination and

  2019-04-22

  

  Case report His physical examination and basic laboratory data were normal. No organic heart disease other than dextrocardia was detected on electrocardiography, chest radiography, and echocardiography (Fig. 1). A head-up tilt test (HUT) was performed according to the ESC/ACC guidelines [7,8]. T

• Any abnormality causing a loss of function in the IKs

  2019-04-22

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

• br Conclusions It is now clear that a number

  2019-04-22

  

  Conclusions It is now clear that a number of synthase are involved in inherited bradyarrhythmia. Recent genetic studies have demonstrated that inherited arrhythmia is attributable to many genes with diverse functions. While the precise underlying mechanisms remain to be elucidated; these genetic

• The prevalence of drug induced type Brugada pattern among pa

  2019-04-22

  

  The prevalence of drug-induced type 1 Brugada pattern among patients with clinical AVNRT was found to be 27.1% by our group [17]. This high prevalence has important implications in terms of the epidemiology of BrS. The prevalence of paroxysmal supraventricular tachycardia (PSVT) (AVNRT and AVRT) in

• Paratyphi A could have a large effect if Vi

  2019-04-22

  

  Paratyphi A could have a large effect if Vi-polysaccharide-conjugate vaccines are introduced in Asia. The absence of the Vi-polysaccharide SCH772984 in Paratyphi A is the most important microbiological discrepancy between Paratyphi A and Typhi; vaccines based on Vi-polysaccharide do not provide

• br Conflict of Interest br Acknowledgments The

  2019-04-22

  

  Conflict of Interest Acknowledgments The authors acknowledge grant from Department of Atomic Energy (DAE), Govt. of India, Grant number: 2013/35/45/BRNS and the technical support of the MSSB (Molecular Stress and Stem Cell Biology) group, School of Biotechnology. We would also like to thank Dr

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