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To date no biomarker analyses of response to VEGFR
2019-05-16
To date, no biomarker analyses of response to VEGFR targeting agents in breast cancer patients with bone predominant metastatic disease has occurred. Although the bone turnover markers serum c-telopeptide (sCTx), and urinary N-telopeptide (uNTx) were measured at baseline, and uNTX measured every 8 w
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In November a year old man with
2019-05-16
In November 2011, a 19-year-old man with no family history of sudden death and a history of syncope was admitted to our hospital after experiencing a sudden cardiac arrest. He suddenly developed abnormal respiration and subsequently experienced convulsions while watching television. His friend, who
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After overdrive pacing excitation that
2019-05-16
After overdrive pacing, excitation that is one lap behind (the second beat after the stimulus) is caused by several mechanisms. One is the prolonged conduction time that is longer than the TCL due to a long conduction pathway and/or slow conduction. The other is the dual-loop reentry [12]. The excit
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Additionally the selection for subcutaneous ICD implant
2019-05-16
Additionally, the selection for subcutaneous ICD implant is based on pre-implant electrographic body surface mapping. The sensing algorithm for this system depends on the surface elecrtrocardiogram (ECG) morphology, specifically the R-and T-wave amplitudes, R/T and R/P ratios, QRS duration and QT in
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br Hematopoietic cell transplantation HCT is generally recom
2019-05-15
Hematopoietic cell transplantation HCT is generally recommended for AML patients with intermediate or high risk cytogenetics, when the aim of treatment is curative. However, elderly patients are seldom offered a transplant mainly due to concerns regarding toxicity, despite the fact that the main
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Vaccinated individuals might represent a
2019-05-15
Vaccinated individuals might represent a safer source of hyperimmune serum. Two vaccine candidates will be tested soon in west Africa. If serum from vaccinated individuals has neutralising activity against the virus in cell models, this serum could be used as adjuvant therapy for EVD. In parallel, a
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El grueso de la poblaci n otavale a de
2019-05-15
El grueso de la población otavaleña de Villanueva lo constituyen parejas jóvenes con niños, indicio de un elevado grado de asentamiento en el contexto de acogida. En oposición al patrón del predominio de varones jóvenes observado por David Kyle en el caso de las migraciones Results Estados Unidos en
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Ante estas opiniones hay que
2019-05-15
Ante estas opiniones, hay que tomar en cuenta que: “investigaciones recientes muestran que los pueblos indígenas han emergido junto olopatadine hcl procesos de revitalización étnica y cultural, que han transformado el escenario sociopolítico y han puesto en tela de juicio las antiguas conceptualizac
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En la condensaci n del
2019-05-15
En la condensación del “Borges y yo” se despliega un texto que tanto puede ser considerado perteneciente al orden de la narrativa como al orden del ensayo, e incluso al de la poesía. En palabras de José Miguel Oviedo, “es un cuento que es también un ensayo que es también un poema”. “No sé quién de l
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We established Wt and two Mt
2019-05-15
We established Wt- and two Mt- (p.R308P and p.A350_N351ins8)-GATA2-expressing 32D Lomustine to analyze the cellular effects of Mt-GATA2 (Fig. 3A). Immunofluorescence analysis revealed that Mt-GATA2 showed similar localization in the nucleus as Wt-GATA2 (Fig. 3B). Both Wt- and mutant-GATA2-expressin
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Previous health emergencies have shown that it can
2019-05-15
Previous health emergencies have shown that it can take time to organise global collective action and provide financing to the national and local level. In such situations, a global mechanism should offer a rapid injection of liquidity to affected countries. The World Bank\'s Pandemic Emergency Fina
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br Discussion In our patient series coronary
2019-05-15
Discussion In our patient series, coronary angiography was performed routinely prior to electrophysiological study, revealing a 9.1% (5/55) incidence of significant coronary artery stenosis in patients with Brugada syndrome/Brugada-type ECG. Although acute myocardial ischemia has been reported to
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br Method br Results br Discussion The present
2019-05-15
Method Results Discussion The present evaluation of ΔFCL in chronic AF patients over a long-term observation order shk revealed a few interesting findings. First, at the end of the 6-year observation period, the mean FCL had prolonged from 154±20ms to 187±37ms in patients with ARB therapy
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Since many decades bone tumours have stimulated imagination
2019-05-15
Since many decades, bone tumours have stimulated imagination of researchers and numerous therapeutic alternatives have been proposed [134,135, Fig. 4]. The better knowledge of OPG/RANK/RANKL system leads to the development of peptides mimicking OPG and blocking RANK–RANKL interactions [136–139]. Inh
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br The role of other bone
2019-05-15
The role of other bone marrow cells in metastatic cancer growth Other cell types also that take part in the regulation of the bone microenvironment, including myeloid and immune cells (T cells), platelets, bone marrow endothelial and haematopoietic cells, as well as bone marrow-derived mesenchyma
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