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Since many decades bone tumours have
2019-05-18
Since many decades, bone tumours have stimulated imagination of researchers and numerous therapeutic alternatives have been proposed [134,135, Fig. 4]. The better knowledge of OPG/RANK/RANKL system leads to the development of peptides mimicking OPG and blocking RANK–RANKL interactions [136–139]. Inh
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Recently emerging data suggest that lower
2019-05-18
Recently emerging data suggest that lower frequency of IV bisphosphonates in metastatic breast cancer has the same efficacy as monthly regimen [48]. ONJ on the other hand can be extremely symptomatic with a severely detrimental effect on quality of life. A case-control study based on risk factors f
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The congruence between BrS and ERS
2019-05-18
The congruence between BrS and ERS with respect to clinical manifestations and response to therapy lends further support to the repolarization hypothesis. Using an experimental model of ERS, Koncz et al. [30]. recently provided evidence in support of the hypothesis that, similar to the mechanism ope
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Al frente de esa disputa Jorge
2019-05-17
Al frente de esa disputa, Jorge Cuesta mostró que la verdadera tradición mexicana no era nacionalista sino cosmopolita, universal; sin duda, estos poemas de Hora y 20, por lo menos, ayudan HZ-1157 comprender la avidez por romper los límites que prevalecía en la mentalidad poética de los Contemporáne
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br Discussion In this pilot study we report that
2019-05-17
Discussion In this pilot study, we report that sequential treatment of low dose clofarabine and lenalidomide is safe and feasible for elderly patients with high risk MDS and AML. Only one subject developed dose limiting toxicity (liver dysfunction) from lenalidomide consolidation therapy. Pre-tre
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br Associated heart disease in
2019-05-17
Associated hydroxylase inhibitor disease in children with ICD implantations In a multicenter ICD registry of 443 patients [8], 69% of the patients had CHD and 23% had cardiomyopathy. The most common heart disease was tetralogy of Fallot (19%), followed by hypertrophic cardiomyopathy (14%) (Fig.
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Macrophages in bone metastasis main
2019-05-17
Macrophages in bone metastasis – main outstanding questions: Conflict of interest statement Acknowledgements IV was supported by a generous grant from Weston Park Hospital Cancer Charity, Sheffield, UK. Introduction In recent years there has been increasing interest in the role of bone-ta
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The miR signature of exosomes
2019-05-17
The miR signature of exosomes isolated from bulk prostate cancer arginase inhibitors (Fig. 1A, blue cells) and from their cancer stem cell compartment (Fig. 1A, green cells), display high levels of miR-21, miR-30 and miR-218 [23] (Fig. 1A, blue arrow). miR-21 and miR-30 have been identified as key
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Introduction Pulmonary vein isolation PVI is an
2019-05-17
Introduction Pulmonary vein isolation (PVI) is an established strategy of paroxysmal atrial fibrillation (PAF) ablation [1–3]. Radiofrequency catheters have been the standard for AF ablation; however, PVI using balloon-based ablation has been increasingly adopted by electrophysiology laboratories a
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br Discussion br Conflict of interest br
2019-05-16
Discussion Conflict of interest Introduction Device implantations may be challenging in patients with venous abnormalities. The most common congenital variation, frequently associated with other congenital abnormalities, is a persistent left superior vena cava (PLSVC), and successful atrial
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src kinase inhibitor br Conflict of interest br Acknowledgme
2019-05-16
Conflict of interest Acknowledgments This study was supported by the National Natural Science Foundation of China (Nos. 81273501 and 81470378). Introduction Sudden cardiac death (SCD) is a tragic event and the aftermath is devastating to the surviving family and community. SCD occurs in ne
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Contraria a la publicidad representativa propia de
2019-05-16
Contraria nampt inhibitor la publicidad representativa, propia de regímenes anteriores al capitalismo, como el feudalismo y la monarquía, centrada en la legitimación del sujeto del poder y expendedora de un “aura” a su autoridad, ligada al atributo de la persona (vestidos, emblemas), sus gestos y su
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br La desaparici n de los aquechistas Las pr cticas
2019-05-16
La desaparición de los aquechistas Las prácticas contrainsurgentes desatadas por el conflicto interno guatemalteco de la administración del general Kjell Eugenio Laugerud García (1974-1978), golpearon dcb diversos actores de la usac. Ejemplo de ello fue el asesinato del abogado Mario López Larrav
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The benign exostoses in TRPS have a recognized malignant pot
2019-05-16
The benign exostoses in TRPS have a recognized malignant potential which have been shown to develop into chondrosarcomas [4,13]. Both our index case and his mother demonstrated de novo high grade osteosarcoma. To our knowledge, this occurrence has not been described anywhere within the literature.
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br Methods The prevalence of various
2019-05-16
Methods The prevalence of various fractionation schedules was extracted from each of the final articles included in the review. Other relevant information, such as significant predictive factors for the use of single fraction SB202190 therapy, changes in the prevalence of fractionation schedules
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