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The redox sensitive transcription factor NF B is reported to
2020-04-14
The redox sensitive transcription factor NF-κB is reported to play a crucial role in the COPD pathogenesis via up regulating the expression of several cytokines, chemokines, growth factors, and adhesion molecules [71]. Incidentally, we and others have shown that PARP-1 modulates the NF-κB activation
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br Effects of culture conditions
2020-04-14
Effects of culture conditions on drug-induced gene Thioguanine in primary human hepatocytes Past progress in elucidating the optimal conditions for the long-term cultivation of rodent hepatocytes has helped define some of the key components in the matrix and medium environment that are most crit
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br Introduction Lung cancer is the
2020-04-14
Introduction Lung cancer is the leading cause of cancer-related death worldwide, accounting for more than 1.5 million deaths in 2012. Non–small-cell lung cancers represent approximately 85% of lung neoplasms; among these, squamous cell carcinomas (SCC) account for approximately 30% of cases. The
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Pathological changes in animal are powerful
2020-04-14
Pathological changes in animal are powerful indicators of the exposure to environmental stressors. The liver serves as an appropriate organ for the study of pollutant effects because of its high capacity to accumulate pollutant and its susceptibility to histopathological damage by pollutants (Padmin
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Although many neurotransmitters e g catecholamines serotonin
2020-04-14
Although many neurotransmitters (e.g., catecholamines, serotonin, and excitatory/inhibitory amino acids) have been implicated in the modulation of anxiety-like responses (Carobrez et al., 2001, Molchanov and Guimaraes, 2002, Vianna et al., 2001), the so-called atypical neurotransmitters, endocannabi
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br Bipartite graph br Algorithm
2020-04-14
Bipartite graph Algorithm for CFC Error detection rate and overhead evaluation Test results and discussion For verifying the proof in nm to lb from the perspective of practice, this section brings tests and analysis based on the onboard computer (OBC) of the in-service ZDPS-1A pico-sate
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Table shows the comparison results of error
2020-04-14
Table 2 shows the comparison results of error detection rate of each software-based CFC technique. Each version of benchmark is injected 10000 errors. Even though the injected errors are randomized in spite of their classifications, the large number of injected errors guarantees that all types of CF
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A more refined picture of cholinesterase activity patterns m
2020-04-14
A more refined picture of cholinesterase activity patterns may be obtained by measuring ChE activity of the same sample before and after addition of certain cholinesterase inhibitors, with differential specificity for different components of total ChE activity, such as BW284c51 (BW1,5-bis-(4-allyldi
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NPC L NPC Niemann Pick C like like intracellular cholesterol
2020-04-14
NPC1L1 (NPC1 [Niemann-Pick C-like-1]-like intracellular cholesterol transporter) is the rate-limiting transmembrane transporter for cholesterol SF1670 from the intestinal lumen, and it mediates the absorption of both dietary and biliary cholesterol., , NPC1L1 is the target of the cholesterol-lower
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Finally we demonstrated for the first time that
2020-04-14
Finally, we demonstrated for the first time that the physiological combinations of estradiol and progesterone levels of premenopausal and postmenopausal women efficiently stimulated the growth of T47D spheroids while clinically relevant concentrations of TPA and UPA suppressed the growth of T47D sph
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Our approach relied on measurement of
2020-04-13
Our approach relied on measurement of bulk solute diffusivity in the three tissue types of interest. Our diffusivity values (Table 3) are on the order of 10−6 cm2/s and are comparable to the PG diffusion coefficient in water at infinite dilution, which is about 10−5 cm2/s at room temperature, as wel
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There have been attempts to stimulate the dopaminergic syste
2020-04-13
There have been attempts to stimulate the dopaminergic system to influence cognition in women around menopause who have subjective complaints about their cognition by Epperson et al. (Epperson et al., 2011, Epperson et al., 2015). In perimenopausal and postmenopausal women, Epperson et al. found tha
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br Methods br Results br Discussion Literature showed SN was
2020-04-13
Methods Results Discussion Literature showed SN was well studied for its antigastric ulcer, antiinflammatory, antihyperglycemic, and antihyperlipidemic properties. Although a recent publication reported that SN was found to exert its regulatory effect in animal cholesterol levels, the exact
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Moreover the imbalance between pro and anti
2020-04-13
Moreover, the imbalance between pro and anti-inflammatory cytokine production is present in various types of diseases. The use of substances able to induce anti-inflammatory cytokines could represent an important advance in the therapeutic treatment of a range of diseases. In this context, medicinal
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In addition to an action via P Y receptors extracellular
2020-04-13
In addition to an action via P2Y receptors, extracellular UDP activates GPCRs for cysteinyl leukotrienes (CysLT1, CysLT2; Mellor et al., 2001, 2003). GPR17 has been reported to function as a receptor for cysteinyl leukotrienes and uracil nucleotides (Boda et al., 2011; Fumagalli et al., 2011; but se
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