• br Discussion The natural history

  2019-04-22

  

  Discussion The natural history of PMF is characterized by the possibility of blastic transformation in approximately 20% of all the cases [9]. Several factors might predict leukemic transformation, including percentage of circulating blasts, low platelets count and the presence of an unfavorable

• In Taiwan the crude incidence rate of

  2019-04-22

  

  In Taiwan, the crude incidence rate of colorectal cancer among male and female populations increased from 49.98 to 69.90, and 39.48 to 51.36 per 100,000 people, respectively, during the DIG-11-dUTP between 2006 and 2011. The observed 2-year survival rates of colon cancer in 2004–2006, 2007–2009 and

• We herein report a patient

  2019-04-22

  

  We herein report a patient with dMMR and MSI-H metastatic gastric cancer who prostaglandin receptor responded favorably and durably to PD-1 blockade. This patient, along with the previous two demonstrated by Le et al, are up-to-date the only 3 MMR gastric cancer patients who responded well to PD-1

• br Case report His physical examination and

  2019-04-22

  

  Case report His physical examination and basic laboratory data were normal. No organic heart disease other than dextrocardia was detected on electrocardiography, chest radiography, and echocardiography (Fig. 1). A head-up tilt test (HUT) was performed according to the ESC/ACC guidelines [7,8]. T

• Any abnormality causing a loss of function in the IKs

  2019-04-22

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

• br Conclusions It is now clear that a number

  2019-04-22

  

  Conclusions It is now clear that a number of synthase are involved in inherited bradyarrhythmia. Recent genetic studies have demonstrated that inherited arrhythmia is attributable to many genes with diverse functions. While the precise underlying mechanisms remain to be elucidated; these genetic

• The prevalence of drug induced type Brugada pattern among pa

  2019-04-22

  

  The prevalence of drug-induced type 1 Brugada pattern among patients with clinical AVNRT was found to be 27.1% by our group [17]. This high prevalence has important implications in terms of the epidemiology of BrS. The prevalence of paroxysmal supraventricular tachycardia (PSVT) (AVNRT and AVRT) in

• Paratyphi A could have a large effect if Vi

  2019-04-22

  

  Paratyphi A could have a large effect if Vi-polysaccharide-conjugate vaccines are introduced in Asia. The absence of the Vi-polysaccharide SCH772984 in Paratyphi A is the most important microbiological discrepancy between Paratyphi A and Typhi; vaccines based on Vi-polysaccharide do not provide

• br Conflict of Interest br Acknowledgments The

  2019-04-22

  

  Conflict of Interest Acknowledgments The authors acknowledge grant from Department of Atomic Energy (DAE), Govt. of India, Grant number: 2013/35/45/BRNS and the technical support of the MSSB (Molecular Stress and Stem Cell Biology) group, School of Biotechnology. We would also like to thank Dr

• br How do you manage patients on

  2019-04-20

  

  How do you manage patients on intravenous bone-targeted agents who require dental work? For patients who are on IV bisphosphonate therapy and require dento-alveolar procedures there is a suggestion that prophylactic antibiotic use around the procedure may be helpful in reducing ONJ risk [45,49].

• br Dissemination permissive characteristics of the BM

  2019-04-20

  

  Dissemination-permissive characteristics of the BM vascular niche Sinusoids (type L capillaries) are the most abundant blood vessels in bone and widely distributed throughout the bone marrow cavity [8]. Sinusoids in bone are discontinuous single layer of endothelial order Cardiogenol C devoid of

• Acknowledgement br Introduction Pulmonary veins PVs have bee

  2019-04-20

  

  Acknowledgement Introduction Pulmonary veins (PVs) have been reported to be the major site of ectopic foci initiating paroxysmal atrial fibrillation (AF) [1]. Pulmonary vein isolation (PVI) is an established therapy eliminating those foci [2,3]. Non-PV ectopic foci from the superior vena cava (S

• p2x7 Despu s de marcharse de la

  2019-04-20

  

  Después de marcharse de la India Paz publica , una obra ensayística que sirve como continuación de y comentario sobre la revuelta de los estudiantes mexicanos que precedió p2x7 la masacre. En este libro Paz postula que la corrupción del lenguaje es la primera señal de un problema grave a nivel soci

• br Drug resistant tuberculosis threatens to undermine advanc

  2019-04-20

  

  Drug-resistant tuberculosis threatens to undermine advances in tuberculosis control worldwide. Multidrug-resistant tuberculosis (MDRTB), defined as resistance to isoniazid and rifampicin, requires treatment for up to 24 months with expensive diagnostics and second-line drugs. Fewer than 15% of pat

• Introduction Acute acalculous cholecystitis ACC is defined a

  2019-04-20

  

  Introduction Acute acalculous cholecystitis (ACC) is defined as an acute necroinflammatory disease of the gallbladder in the absence of cholelithiasis and has a multifactorial pathogenesis [1]. ACC has very rarely been described in patients undergoing myelosuppressive chemotherapy for acute myelobl

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