• br Introduction In addition to ATP production

  2024-10-12

  

  Introduction In addition to ATP production, an important role of mitochondria in the pancreatic beta cell is anaplerosis, which is the net synthesis of citric Cy3 hydrazide cycle intermediates that are exported to the cytosol where they are converted to numerous other metabolites that stimulate a

• The results of our in vivo experiments provide promising

  2024-10-12

  

  The results of our in vivo experiments provide promising evidence that the apelin/APLNR axis is implicated in CCA growth and that targeting this axis with a receptor specific antagonist may help develop effective, tumor directed therapies. Not only do we show decreased proliferation and angiogenesis

• Based on the general structure

  2024-10-11

  

  Based on the general structure-function principle in biology [[19], [20], [21]], toxic oligomers are expected to have well-defined three-dimensional structures to carry out their pathological functions. A common amyloid toxicity mechanism also suggests that toxic oligomers of different amyloid prote

• A has been reported to decrease insulin receptors and impair

  2024-10-11

  

  Aβ has been reported to decrease insulin receptors and impair insulin signaling in neurons, preventing phosphorylation of Akt and glycogen synthase kinase 3β (GSK-3β), downstream of insulin signaling, and to increase phosphorylation of tau protein causing neurofibrillary tangles (Tokutake et al., 20

• KT203 br Experimental procedures br Results

  2024-10-11

  

  Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this KT203 work. SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We would like to thank Dr

• Heat shock protein Hsp is a molecular chaperone that plays

  2024-10-11

  

  Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a central role in regulating the maturation, activation and stability of numerous “client proteins” that drive the development and progression of many cancers. Therefore, inhibition of Hsp90 would result in degradation of the client p

• OCT also is known as POU F

  2024-10-11

  

  OCT4 (also is known as POU5F1) plays an important role in embryonic stem cell self-renewal, development and reprogram somatic cell into pluripotent stem cell [[5], [6], [7]]. Recently, many studies also find OCT4 promotes the progression of many tumors. For example, Wnt/β-catenin promotes the expans

• In a recent series of studies

  2024-10-11

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat melk inhibitor wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced

• The Cebu Longitudinal Health and Nutrition Survey CLHNS

  2024-10-11

  

  The Cebu Longitudinal Health and Nutrition Survey (CLHNS) genome-wide association study investigated the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women. Adiponectin was strongly associated with three genetic positions: the gene CDH13 (rs3865188, P ≤ 7.2 × 10−16), ne

• br Conclusions br Acknowledgments This

  2024-10-11

  

  Conclusions Acknowledgments This research was funded by the National Science Foundation Committee (NSFC) of China (Nos. 81171058 and 81471146) and Capital Development Scientific Research in China (Nos. 2011-5001-04 and 2014-4-5013). We are grateful for all of the participants who donated blood

• Adenosine receptors are proposed to play

  2024-10-11

  

  Adenosine receptors are proposed to play proangiogenic role in vascular and immune Spectinomycin hydrochloride hydrate within microenvironment of hypoxic tissues to maintain tissue oxygenation in chronic ischemic condition [9]. Adenosine also stimulates the production of angiopoetin-1, VEGF and Int

• Finally one can ask whether these results throw any

  2024-10-11

  

  Finally, one can ask whether these results throw any light on the nature of the target in SNMG patients. Interestingly, the results of the in vitro incubations suggested that SNMG sera might increase AChR expression to a small extent, raising the possibility that SNMG patients, who have thymic chang

• By performing knockdown of AXL once

  2024-10-11

  

  By performing knockdown of AXL once HER2+ cancer palbociclib have achieved lung colonization, we demonstrated that AXL contributes to the establishment of macrometastases. While inhibition of AXL impairs the efficiency of metastasis, the later finding has major clinical implications since pharmacolo

• Aurora B is also very

  2024-10-11

  

  Aurora-B is also very important in proper cytokinesis. In the absence of Aurora-B mediated phosphorylation of Ser72 in vimentin, the two daughter cells remain attached to each other through bridges of cytoplasm; cytokinesis fails [31]. Other Aurora-B dependent proteins that are important for cytokin

• In the last decade the zebrafish has emerged as

  2024-10-11

  

  In the last decade, the zebrafish has emerged as a valuable vertebrate model to systematically dissect the genetic underpinnings of both vertebrate heart development and function [8,9], as well as distinct cardiac diseases such as congenital heart disease [10], cardiomyopathies [11,12] and cardiac a

15395 records 71/1027 page Previous Next First page 上5页 7172737475 下5页 Last page