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H R antagonism can prevent seizure development and improve
2021-10-27
H3R antagonism can prevent seizure development and improve working memory through the activation of histaminergic neurons (Huang et al., 2004, Zhang et al., 2003). In addition, we have recently found that H3R antagonism protects against ischemia-reperfusion injury via histamine-independent mechanism
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Hh signaling pathway plays an essential
2021-10-26
Hh signaling pathway plays an essential role in the regulation of invertebrate and vertebrate tissue development and metabolic homeostasis. Components of Hh signaling pathway have been identified in succession, including Hh ligands, membrane protein receptors, cytoplasmic components and transcriptio
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Previous reports have implicated the
2021-10-26
Previous reports have implicated the guanylin/GC-C signalling system as being important in osmoregulation in fish, especially in euryhaline species such as the eel which migrate between freshwater (FW) and seawater (SW) environments at different stages of their life cycle (Comrie et al., 2001a, Comr
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br Materials and methods br Results br Discussion Directly m
2021-10-26
Materials and methods Results Discussion Directly modulating specific target proteins and signaling pathways with small-molecule drugs or agonistic Azimilide sale is widely used for cancer metastasis therapies [[39], [40], [41]]. ANXA7 acts as a metastasis suppressor in prostate cancer. Ho
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Strengths The primary feature of
2021-10-26
Strengths The primary feature of GPR119 agonists resides in their dual mechanism of action in regulating blood glucose 1, 2, 3, 15. GPR119 agonists stimulate GLP-1 release from intestinal L iox as well as glucose-dependent insulin secretion and insulin promoter activity enhancement in pancreatic β
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br Mechanisms of action Ghrelin is a amino
2021-10-26
Mechanisms of action Ghrelin is a 28-amino Digoxin peptide hormone primarily produced in the oxyntic mucosa of stomach, but also in other gastrointestinal tissues [7] (Fig. 1). It acts as the endogenous ligand for the ghrelin receptor [GHS-R1a] and causes the release of growth hormone from the p
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Amongst oxidants that we have studied PMS is
2021-10-26
Amongst oxidants that we have studied, PMS is unique in having a greater effect in deoxygenated cells. The resulting phenotype shows some similarities with the increased cation permeability shown by deoxygenated sickle Calcein AM sale [27]. It is interesting to consider why PMS has this effect. PMS
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br Materials and methods br Results br
2021-10-25
Materials and methods Results Discussion Several studies highlighted an improvement of glycaemic control in diabetic patients receiving sunitinib, while the underlying mechanism remained still elusive [3], [4], [5], [6], [8]. The present study gives evidence that sunitinib directly and spec
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br Problem of cellular retention not only affects the
2021-10-25
Problem of cellular retention not only affects the cellular activity of the nanoparticles and nanocomplexes but can also have ramifications in their in vivo applications. While inorganic nanoparticles are being developed extensively for detection as well as treatment of different human diseases, i
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br Acknowledgements This research was supported by
2021-10-25
Acknowledgements This research was supported by the Natural Sciences and Engineering Council of Canada (NSERC) Discovery Grant awarded to RGM. LMW was supported in part by fellowships from the University of Regina and the Government of Saskatchewan Fish and Wildlife Development Fund (FWDF). We wo
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It is acknowledged that mitochondrial outer
2021-10-25
It is acknowledged that mitochondrial outer membrane permeabilisation is a pivotal signal for apoptosis, which leads to the liberation of pro-apoptotic molecule such as cytochrome c and post-caspase activation [37]. As a consequence of the protection of mitochondrial integrity, AIV improved mitochon
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br Materials and methods br
2021-10-25
Materials and methods Results Discussion The innate immune system plays an important role in protecting against IAV infections. However, the virus has the ability of escaping the innate immune system. Activating or enhancing an innate immune response before or during a viral infection will
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The effect of microtubule inhibitors on HBV infection and
2021-10-25
The effect of microtubule inhibitors on HBV infection and replication were reported previously. In the study by Dr. Ai-Long Huang's group, microtubule inhibitors promoted HBV replication in Hep2.2.15 and HepG2-HBV1.1, in which HBV DNA is integrated into the chromosomal DNA (Xu et al., 2015). Integra
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Given the role that activation of GC C
2021-10-25
Given the role that activation of GC-C has in stimulating fluid secretion in the intestine, attempts have been made to exploit this pathway to relieve symptoms of chronic constipation. Currently, an orally administered synthetic ST mimic, linaclotide [29], has been successfully shown to alleviate co
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br Role of dynamin in NPRA
2021-10-25
Role of dynamin in NPRA endocytosis In recent studies using 125I-ANP binding assay and confocal microscopy, we have examined the role of dynamin in the internalization and trafficking of NPRA in a stably transfected HEK-293 punicalagin [69]. Our findings indicated that ANP treatment of high-dens
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