• There are multiple E ligases

  2020-08-03

  

  There are multiple E3 ligases that can impact the pathobiology of atherosclerosis [38,39]. For example, HECT domain E3 ligases HUWE1 and NEDD4–1 control stability of the ATP-binding cassette transporter ABCG1 and ABCG4, both critical for cholesterol homeostasis [40]. In addition, the E3 ubiquitin li

• The steric wedge model provides a

  2020-08-03

  

  The steric wedge model provides a structural explanation for some RBR E3s. But not all family members have four-residue Zn-loops II. Parkin has a three-residue loop and two other RBRs, including HOIP, have two-residue loops. A notable difference between HHARI and Parkin is that auto-inhibited HHARI

• br Concluding Remarks Recent studies have provided unprecede

  2020-08-03

  

  Concluding Remarks Recent studies have provided unprecedented details of APC/C structure and enzymology, which explain how the activity of this massive E3 ligase is controlled, and how ubiquitylation is achieved to temporally regulate cell division. Although one pervasive question has been why th

• Our experiments show that the N

  2020-08-03

  

  Our experiments show that the N-terminal ubiquitination results in an overall slowing down of Ube2Es toward the E3/substrate rather than affecting their chain-building capacity. The fact that Ube2E1wt activity is not restricted toward mono-ubiquitination is also evident from Fig. 4a, where the full-

• Routine administration of exogenous GC is

  2020-08-03

  

  Routine administration of exogenous GC is pertinent during late gestation, particularly in women who are at risk of delivering a preterm infant, aiming at ensuring proper neonatal outcome and survival (Kamath-Rayne et al., 2012). Unfortunately, despite its beneficial roles in foetal survival, variou

• Nepicastat is well tolerated in healthy

  2020-08-03

  

  Nepicastat is well tolerated in healthy adults and in patients with congestive heart failure (Hegde and Friday, 1998) (Roche Biosciences, unpublished observations) and may represent a better tolerated, more efficacious treatment for cocaine use disorder than disulfiram. As such, the present study wa

• Due to their ability to hydrolyze

  2020-08-03

  

  Due to their ability to hydrolyze rhamnose from natural flavonoids, α-RHAs are used in several biotechnological applications. Some examples include the hydrolysis of naringin to improve beverage quality by debittering grapefruit and citrus juices [12,13], and the removal of hesperidin crystals from

• Over the past decade an increasing number of small molecule

  2020-08-03

  

  Over the past decade, an increasing number of small-molecule DGAT-1 inhibitors had been developed with variable structural types.13, 14, 15 Most (Fig. 1) share a privileged structure with the heteroaryl-linker-acid, which is based on compounds 1 and 2 described in the early patents of Japan Tobacco/

• The SEC in cfALDH is

  2020-08-03

  

  The SEC in cfALDH is predicted to have a volume between that seen in the sheep ALDH1A1 (Volume 670.2 Å3) and the human ALDH2 (Volume 558.07 Å3) with a calculated volume of 635.05 Å3 when the sheep ALDH1A1 1BXS is used as the template (Fig. 4b). The GQCC motif is at the bottom of the SEC in cfALDH as

• Collagen compaction and alignment are

  2020-08-03

  

  Collagen compaction and alignment are generated by cell-mediated contractile forces (Stopak and Harris, 1982). The transmission of actomyosin forces to collagen has been mainly attributed to integrins and the activation of the Rho-ROCK pathway (Clark et al., 2007, Kural and Billiar, 2013, Provenzano

• Introduction br Material and methods br

  2020-08-01

  

  Introduction Material and methods Results Discussion The high degree of conservation of the prolyl-4-hydroxylase active site between the cone snail sequences and the Homo sapiens, Gallus gallus and Bos taurus prolyl-4-hydroxylase, suggests that only the hydroxylation prone proline residue

• Our studies investigating a role for

  2020-07-31

  

  Our studies investigating a role for integrins in collagen induction of lysyl oxidase may also suggest a cooperative function for integrins in DDR2-mediated up-regulation of lysyl oxidase by collagen. It is interesting to note, however, that the level of 32kDa lysyl oxidase in the presence of EDTA w

• Our work explains the previously enigmatic observation that

  2020-07-31

  

  Our work explains the previously enigmatic observation that the polarized nuclear organization that defines the transition zone is extended greatly in synapsis-defective mutants (Colaiácovo et al., 2003, MacQueen et al., 2002, Phillips et al., 2005). Synapsis is initiated in the transition zone, and

• BQ-123 In the present study we examined whether the gene

  2020-07-31

  

  In the present study we examined whether the gene for estrogen receptor alpha, Esr1, plays a role in the expression of maternal memory in female rats. The approach utilized a newly developed rat Esr1 knockout (KO) rat model (Rumi et al., 2014) to evaluate whether deletion of the Esr1 BQ-123 affecte

• br Competing interests br Funding br Ethical approval br

  2020-07-31

  

  Competing interests Funding Ethical approval Acknowledgments Introduction Primitive neuroectodermal tumors (PNETs) are malignant, small round cell tumors of neural crest origin which typically arises from bone or soft tissue in the trunk/axial skeleton/paraspinal regions in adolescent

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