• The use of cement as the main

  2020-08-08

  

  The use of cement as the main binding material has been in practice over the last 50 years [17]. It has been reported that the manufacturing of one ton of Portland cement contributes to the environment one ton of CO2 emission [18]. With the increasing contribution of the cement industry to the glob

• L-Mimosine With respect to CYP A the Kaempferia

  2020-08-08

  

  With respect to CYP1A2, the Kaempferia parviflora extract presented a mixed-type interaction pattern with an increase in both Vmax and Km suggesting that it might bind to both the active site of the enzyme and an allosteric site. Interference with the allosteric site of CYP1A2 could modify the confo

• Oxysterols tend not to be observed in global lipidomic

  2020-08-08

  

  Oxysterols tend not to be observed in global lipidomic analysis, whether shot-gun based electrospray ionisation – mass spectrometry (ESI-MS) or liquid chromatography (LC)-MS based. This is because of their comparatively low-abundance and poor ionisation characteristics. However, methods have been de

• As a newly emerging technology nanoparticles or

  2020-08-07

  

  As a newly emerging technology, nanoparticles or nanoclusters templated by DNA have attracted research interest as these ISO-1 have the advantages of simplifying synthesis, utilizing flexible mechanisms and powerful signals, and having low cost, as well as the ability to be templated by proteins or

• The proliferation of CCA cell

  2020-08-06

  

  The proliferation of CCA cell lines can be stimulated by bosentan and other growth factors (Alvaro et al., 2006; DeMorrow, 2009; Mancino et al., 2009). It has also been reported that estrogen positively modulates cholangiocyte proliferation, which is associated with cholangiopathies found in humans

• br Inhibiting DDR what we know and what we should

  2020-08-06

  

  Inhibiting DDR: what we know and what we should know The contribution of DDRs to fibrotic diseases and cancer progression indicates that blocking these receptors might represent a promising therapeutic strategy. A plausible approach is to prevent DDR expression (Fig. 3), as DDR levels increase si

• One of the most abundant natural flavonols quercetin has

  2020-08-06

  

  One of the most abundant natural flavonols quercetin has previously been shown to potently inhibit CYP2E1 and CYP3A4 activity in vitro in different species including humans (Rastogi and Jana, 2014), pigs (Ekstrand et al., 2015), and rats (Zhou and Tang, 2005). Gender-related differences in the inter

• Ertapenem sodium salt The estrogen related receptor ERR orph

  2020-08-06

  

  The estrogen-related receptor (ERR) orphan receptor subfamily comprises three subtypes, ERRα, ERRβ, and ERRγ. The ERRs are first orphan nuclear receptors identified based on their structural similarity with the estrogen receptor (ER). Although it was originally believed that the developmental and ph

• Early diagnosis of CVS and DCI is a key issue

  2020-08-05

  

  Early diagnosis of CVS and DCI is a key issue in the management of SAH patients. In this regard, CT Perfusion (CTP) is the most accurate and sensitive method for noninvasive imaging assessment of cerebral ischemia with a great value for prediction and early diagnosis of CVS and DCI. CTP is a relativ

• GLP also showed cardioprotective effects i e infarct

  2020-08-05

  

  GLP-1 also showed cardioprotective effects (i.e., infarct size reduction and ejection fraction improvement) in experimental models of myocardial ischemia-reperfusion injury by suppressing caspase-3 activation and preventing apoptosis of cardiomyocytes [[50], [51]]. Of note, such a cardioprotection w

• The interest in DAPK as a central nervous system CNS

  2020-08-05

  

  The interest in DAPK as a CHIR-090 drug discovery target is based on the in vivo role of DAPK in animal model disease progression that is dependent on the kinase domain\'s catalytic activity [2], [3], [4], [5], [6]. Bioavailable DAPK inhibitors administered during clinically relevant therapeutic ti

• A series of former studies provided preliminary indirect evi

  2020-08-05

  

  A series of former studies provided preliminary indirect evidence that the nucleo-cytoplasmic transport of mRNAs encoding CD83 may be specifically regulated in DC. For example, the cytoplasmic accumulation of a small subset of cellular transcripts, including CD83 mRNA, appears to depend on a functio

• Impulsive burying and freezing behaviors in

  2020-08-05

  

  Impulsive burying and freezing behaviors in response to aversive stimuli may represent attempts to avoid novel and/or aversive stimuli. These behaviors can be assessed utilizing the marble burying and conditioned fear tasks, respectively. For example, Wistar rats in proestrus and ovariectomized rats

• ESC originally appeared to be unique among PcG

  2020-08-05

  

  ESC originally appeared to be unique among PcG proteins in being required predominantly during early embryogenesis. Temperature shift experiments with a temperature-sensitive esc allele suggested that esc is required only during early embryogenesis (Struhl and Brower, 1982) and similar experiments w

• How does an increase in E affinity for the

  2020-08-04

  

  How does an increase in E2 affinity for the RING domain favor higher activity and polyubiquitination by the E2? Binding of the RING domain to the E2 positions the donor Ub in the E2~Ub conjugate in a closed complex [16], [17], [18] that increases the reactivity of the thioester [60]. A higher affini

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