• To confirm that these were bona fide

  2022-06-20

  

  To confirm that these were bona fide interactions, we investigated whether the potassium channel subunits or Tmem263 formed complexes with GLT-1 or DAT after immunoprecipitation. Lysates of HEK-293 cells previously cotransfected with HA-GLT-1 or HA-DAT, and either YFP-Kv7.3, YFP-Kv7.2 or YFP-Kv7.5 w

• Whereas accurate measurement of glucagon in humans has been

  2022-06-18

  

  Whereas accurate measurement of glucagon in humans has been possible since the early 1950s proper measurements in rodents, have not. That said, plasma concentrations of glucagon have been reported in rodent studies [21] using C-terminal specific methods but what has been lacking is the secretory dyn

• Together our data are consistent with

  2022-06-18

  

  Together, our data are consistent with the idea that the antidepressant-like effect of a low dose of galanin administration in the DRN would be mediated by the activation of local GAL2. To support this hypothesis, we set an additional experiment to evaluate whether the antidepressant-like effect of

• Introduction galactosidase d galactoside galactohydrolase or

  2022-06-18

  

  Introduction β-galactosidase (β-d-galactoside galactohydrolase or lactase; EC 3.2.1.23) is an important type of glycoside hydrolase that can catalyze the conversion of lactose to betaxolol and galactose. Furthermore, it can also catalyze transglycosylation reactions, which are usually used for the

• br Molecular aberrations in the FGFR signaling pathway

  2022-06-18

  

  Molecular aberrations in the FGFR signaling pathway Non–small cell lung cancer Small cell lung cancer Integrated JQ1 analysis revealed focal amplification of FGFR1 in 6% of SCLC cases. In another study with PD173074, Pardo et al. used two human SCLC xenograft models, H-510 and H-69, and de

• br Other strategies for ferroptosis In addition

  2022-06-18

  

  Other strategies for ferroptosis In addition to ROS-generating and GPX4 inactivating nanomaterials, small molecules and genetic manipulation targeting key factors in the ferroptosis pathway have also been tested for their anticancer effects [39,47,48]. Among a myriad of proteins involved in ferro

• Earlier findings from different cancer entities such as chro

  2022-06-18

  

  Earlier findings from different cancer entities such as chronic myeloid leukemia (Yang et al., 2011), B cell chronic lymphocytic leukemia (Jantus Lewintre et al., 2009), prostate cancer (Zhu et al., 2009), epithelial ovarian cancer (Tokunaga et al., 2008), and colon cancer (Mazzoccoli et al., 2016,

• The stability and function of the HIF

  2022-06-18

  

  The stability and function of the HIF-1α protein are affected by many post-translational modifications (PTMs), including hydroxylation, acetylation, ubiquitination and SUMOylation [[29], [30], [31]]. It has been shown that HIF-1α stability is regulated by LSD1 [25]; in particular, the Set9 histone m

• Preadipocytes are capable of differentiating

  2022-06-18

  

  Preadipocytes are capable of differentiating into lipid-laden mature adipocytes. Lipid droplets are a prominent morphological feature of mature adipocytes, which is accumulated and maintained during adipocytes differentiation [26]. In this study, rHhip treatment increased lipid accumulation, as well

• br Structural Homology and Functional

  2022-06-18

  

  Structural Homology and Functional Implications Amino Neurotensin receptor sequence analyses of Disp and the Shh receptor Ptch indicate that both proteins share structural homology with a family of bacterial efflux pumps that function in resistance, nodulation, and division (RND) transporter com

• glycogen phosphorylase There is evidence for an adverse

  2022-06-18

  

  There is evidence for an adverse sympatho-stimulatory effect in the medulla oblongata mediated by the α1/β1 isoform, implying a possible benefit of selective α2/β1 activation [19]. While the stimulator BAY 41–2272 increases NO-sensitivity of both isoforms [20], a prevalence of the α1/β1 isoform comp

• br Role of dynamin in NPRA endocytosis In

  2022-06-18

  

  Role of dynamin in NPRA endocytosis In recent studies using 125I-ANP binding assay and confocal microscopy, we have examined the role of dynamin in the internalization and trafficking of NPRA in a stably transfected HEK-293 Fmoc-Leu-OH [69]. Our findings indicated that ANP treatment of high-dens

• PRT 4165 australia Mice lacking S nitrosoglutathione reducta

  2022-06-18

  

  Mice lacking S-nitrosoglutathione reductase (GSNOR), a denitrosylase that regulates S-nitrosylation, have increased levels of S-nitrosoglutathione (GSNO) and exhibit nitrosative stress. GSNO is in equilibrium with protein S-nitrosylation in cells, and GSNOR controls the cellular concentration of pro

• br GPR GPR has been described as a type

  2022-06-18

  

  GPR55 GPR55 has been described as a type 3 cannabinoid receptor due to its ability to detect endocannabinoids and may play a role in the endocannabinoid lipid sensing system [28]. GPR55 is activated by both cannabinoid endogenous agoinsts (endocannabinoids) and non-cannabinoids fatty acids namely

• Similar to GPR A activation

  2022-06-17

  

  Similar to GPR109A, activation of G-protein-coupled receptor 81 (GPR81, also called HCAR1 (hydroxycarboxylic 5-Methyl-UTP receptor 1)) by lactate suppresses lipolysis (Fig. 1), suggesting GPR81 to be a potential drug target for treating T2DM (Boyd et al., 1974, Cai et al., 2008, Gold et al., 1963,

15395 records 409/1027 page Previous Next First page 上5页 406407408409410 下5页 Last page