• The biology of the A BR

  2023-03-02

  

  The biology of the A2BR is complex and needs to be considered contextually as the expression and effect of receptor engagement varies according to time post hypoxic injury, cell type and downstream signaling pathway. For example, A2BR expression is dynamic - low under basal and increasing under isch

• We investigated the role of ABT treatment in MAPKinase

  2023-03-02

  

  We investigated the role of ABT 702 treatment in MAPKinase activation in mouse microglia in vitro. In Fig. 7D immunocytochemistry results revealed that Iba1 and p-ERK1/2 co-localized in LPS induced mouse microglia. In our previous study we have reported that LPS activates ERK1/2 phosphorylation (Ahm

• There has been growing interest over

  2023-03-02

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it 5α-dihydro-11-keto Testosterone has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activit

• Apoptosis or programmed cell death is a function

  2023-03-02

  

  Apoptosis or programmed cell death is a function of biochemical mechanisms, which are energy-dependent. It is considered to be a vital component of many processes such as normal cell cycle, immune mechanism, atrophy, embryonic development and toxin-induced cell death (Elmore, 2007). In addition, apo

• The structure of LO is divided in

  2023-03-02

  

  The structure of 5-LO is divided in two domains, the catalytic C-terminal domain and the N-terminal regulatory C2-like domain (C2ld) [59,60]. The C2ld spans the beta lapachone 1-114 and is responsible for translocation and binding of calcium and membranes [61–63]. The catalytic domain is primarily a

• br Acknowledgments This work was supported by a grant of

  2023-03-02

  

  Acknowledgments This work was supported by a grant of the Romanian National Authority for Scientific Research, CNCS – UEFISCDI, project no. PN-II-ID-PCE-2011-3-0571, awarded to F.A.M. D.V.N. was co-financed from the European Social Fund through Sectorial Operational Program Human Resources Develo

• The synthesis and secretion of adrenal androgens is

  2023-03-02

  

  The synthesis and secretion of adrenal androgens is apparently unique to humans and nonhuman primates, and requires the expression of key mediators such as CYP17 [26]. Endocrine control of CYP17 expression in rhesus monkeys is comparable to that in humans [27]. An analysis of baboon cDNA for CYP17 s

• br In vivo visualization of aromatase with positron emission

  2023-03-02

  

  In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high Ciprofibrate photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the living bod

• br Dysregulated aromatase expression the link between obesit

  2023-03-02

  

  Dysregulated aromatase expression: the link between obesity and breast cancer Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, influencing the local production and bioavailability of estrogens (Morris et al, 2011, Subbaramaiah et al, 2012). Bowers

• br Acknowledgement br Introduction Estrogens play

  2023-03-01

  

  Acknowledgement Introduction Estrogens play an important role in the development and progression of breast cancer (McGuire et al., 1976; Clemons and Goss, 2001). 17β-Estradiol (E2), the most biologically active estrogen in breast tissue, functions via its nuclear receptors, estrogen receptor (

• The renin angiotensin system RAS is

  2023-03-01

  

  The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid cddo [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) and angiotensin t

• It has been proposed that

  2023-03-01

  

  It has been proposed that angiotensin II (Ang II) may upregulate COX-2 expression and the subsequent vasoconstrictor prostanoids production through the activation of AT-1 receptors in vascular smooth muscle cells (Hu et al., 2002). Additionally, this peptide is also able to stimulate the generation

• Earlier studies with SERMs identified that distinct chemical

  2023-03-01

  

  Earlier studies with SERMs identified that distinct chemical scaffolds have the ability to induce unique conformational changes in the ER, resulting in interaction with different cofactor subsets. The same has been demonstrated with SARMs, which induce distinct conformational changes compared to tes

• The importance of TARPs for AMPAR expression and

  2023-03-01

  

  The importance of TARPs for AMPAR expression and function was revealed initially in the cerebellum, where the lack of γ-2 in the mutant mice waggler and stargazer (stg/stg) was associated with a selective loss of AMPAR-mediated synaptic currents in cerebellar granule Lauric Acid synthesis (Chen et 

• Introduction Lipoxygenases LOXs are key enzymes that catalyz

  2023-03-01

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic folate analogue (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Claess

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